EJ Manuel threw for a career-high 380 yards and two touchdowns and ran for another 102 yards as fourth-ranked Florida State rallied from a two-touchdown deficit to defeat No. 10 Clemson 49-37 on Saturday night. The biggest Atlantic Coast Conference game in years was a wild one for a while. Then it was Florida State’s offense pulling away from Clemson and it’s fast-paced attack. Chris Thompson ran for 103 yards and two scores and James Wilder Jr. added two touchdown runs for the Seminoles, who broke open a close game with 35 second-half points. Thompson, who has 300 yards rushing in two ACC games, also caught eight passes for 79 yards. Florida State (4-0. 2-0 ACC) trailed until late in the third quarter, taking its first lead at 35-31 on Manuel’s 29-yard touchdown pass to Rodney Smith. The Seminoles, who finished with 667 yards, built a 49-31 lead before Clemson scored late. Florida State is now the only remaining unbeaten team in the ACC.