In two years time, according to an estimate from the Census Bureau, Seneca’s population fell by four residents. In the 2010 Census, Seneca sported a population of 8, 102. Two years later, Oconee’s largest municipality lost four residents, for a current estimated population of 8,098. Nearby Clemson is gaining residents. The Census Bureau reports that the city of Clemson grew 127 residents—from its 2010 census count of 13,962 to today’s estimate of 14,089.